Effect ofNQO1andCYP4F2genotypes on warfarin dose requirements in Hispanic–Americans and African–Americans
نویسندگان
چکیده
منابع مشابه
Effect of ageing upon warfarin dose requirements: a longitudinal study.
This longitudinal study was designed to establish the rate of age-related change in warfarin dose requirements. Warfarin dosage was recorded retrospectively in 104 patients who had been stabilized on warfarin for a median period of 10 years (range 6-24 years) for prophylaxis of thromboembolic disease. There was a significant negative correlation between dosage and age at the start of therapy (p...
متن کاملEffect of CYP2C9 and VKORC1 genetic variations on warfarin dose requirements in Indian patients.
BACKGROUND Warfarin, an oral anticoagulant is used in patients who are at increased risk of developing blood clots. The management of warfarin therapy is challenging because it shows large inter and intra individual variability in patient response due to factors like age, gender, diet, concurrent drug interactions and variations in CYP2C9 and VKORC1 genes. Studies implicate that polymorphisms i...
متن کاملThe effect of CYP2C9 and VKORC1 genetic polymorphisms on warfarin dose requirements in a pediatric population
OBJECTIVE The aim was to investigate the frequency of genetic polymorphisms of cytochrome P4502C9 (CYP2C9) and vitamin K epoxide reductase complex subunit1 (VKORC1) and determine the effect of these polymorphisms on warfarin dose requirements in pediatric patients. METHODS Fifty-eight pediatric patients with cardiac disease, thrombophilia, or other conditions, taking a stable warfarin dose, a...
متن کاملeffect of bataine and sulphate supplement on wool and milk characteristics and lambs performance in naine ewes
تعداد 20 رأس میش نژاد نائینی 6+-24 ماهه، با میانگین وزن 2/3-+40 کیلوگرم، همراه با 20 رأس بره های آنها در قالب طرح کاملا تصادفی اثر بتائین و مکمل سولفات بر خصوصیات شیر و پشم و عملکرد بره ها بررسی شد. میش ها بطور تصادفی در چهار تیمار قرار گرفتند. تیمارها عبارت بودند از: 1-گروه شاهد 2-بتائین (05/0 درصد ماده خشک) 3-سولفات (24/0 سولفور درصد ماده خشک 4-بتائین هرماه با سولفات. جیره غذائی طبق nrc با مح...
15 صفحه اولEffect of VKORC1 haplotypes on transcriptional regulation and warfarin dose.
BACKGROUND The management of warfarin therapy is complicated by a wide variation among patients in drug response. Variants in the gene encoding vitamin K epoxide reductase complex 1 (VKORC1) may affect the response to warfarin. METHODS We conducted a retrospective study of European-American patients receiving long-term warfarin maintenance therapy. Multiple linear-regression analysis was used...
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ژورنال
عنوان ژورنال: Pharmacogenomics
سال: 2012
ISSN: 1462-2416,1744-8042
DOI: 10.2217/pgs.12.164